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| Product Name: |
Pam2CSK4
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| Supply Ability: |
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| Related proudcts |
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| Specifications |
Pam2CSK4 |
| Price Term: |
FOB |
| Port of loading: |
Chengdu |
| Minimum Order |
100mg |
| Unit Price: |
1-1000USD |
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Specificity: TLR2(6) agonist
Working concentration: 1 - 100 ng/ml
CAS number: 868247-72-7
Molecular formula: C65H126N10O12S, 3TFA
Molecular weight: 1271.85
Solubility: 1 mg/ml in water
Pam2CSK4 is a synthetic diacylated lipopeptide (LP). Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection.
LP analogues of these lipoproteins signal either through TLR2/1 or TLR2/6 heterodimers. According to the current model, triacylated LP like Pam3CSK4, are recognized by TLR2/1, whereas diacylated LP, such as FSL-1, induce signaling through TLR2/6.
However, it was reported that diacylated LP, such as Pam2CSK4, induce signaling in a TLR6-independent manner [1]. This finding suggests that both the lipid and peptide part of lipoproteins take part in the specificity of recognition by TLR2 heterodimers.
When combined with a TLR9 agonist, Pam2CSK4 was found to promote resistance against bacterial pneumonia via a TLR2-MyD88-dependent pathway [2]. It has also been demonstrated that Pam2CSK4 promotes IL-1β maturation and release from macrophages through an NLRP7-containing inflammasome [3].
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| Company: |
Chengdu Youngshe Chemical Co.,ltd
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| Contact: |
Ms. Cecilia Jiang |
| Address: |
Jitai RD |
| Postcode: |
610000 |
| Tel: |
+86-18108235634 |
| Fax: |
86-028-62328193 |
| E-mail: |
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