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| Product Name: |
Lipospondin
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| Supply Ability: |
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| Related proudcts |
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| Specifications |
1g for one bottle |
| Price Term: |
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| Port of loading: |
Chengdu |
| Minimum Order |
50mg |
| Unit Price: |
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Lipospondin
1.Basic information:
Name: Lipospondin
Cas No:
Formula: C21H35N5O4
Molecular:685
Sequence: N-Elaidoyl-KFK
Purity: ¨R95%
Grade: cosmetic
Source: synthetic
Stability: stable
Appearance: white powder
MSDS and COA: available for your reference
Delivery: promptly from stock
Appearance: white powder
2.Usage: prevent age-associated dermal alterations
3.Description£ºN-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of ***-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations.
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| Company: |
Chengdu Youngshe Chemical Co.,ltd
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| Contact: |
Ms. Cecilia Jiang |
| Address: |
Jitai RD |
| Postcode: |
610000 |
| Tel: |
+86-18108235634 |
| Fax: |
86-028-62328193 |
| E-mail: |
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